Effect of RvD1 treatment on kidney fibrosis in ADR nephropathy.

<p>Graphs of (A) glomerulosclerosis, and (B) interstitial fibrosis, for normal saline (NS) controls, and day 28 ADR with vehicle treatment or with early (28d) or late (14d) RvD1 treatment. (C) Confocal microscopy showing immunostaining for α-smooth muscle actin (α-SMA), fibronectin and collagen IV expression in the above experimental groups in ADR nephropathy. (D) Graph quantifying the area of interstitial staining for α-SMA, fibronectin and collagen IV in ADR nephropathy. Data are mean ± SD, n = 6. ^*<i>P</i>&lt;0.05 versus NS; ^#<i>P</i>&lt;0.05 <i>vs</i> ADR+Vehicle and <i>vs</i> ADR+RvD1_14d. Original magnification, x600 (C).