Inhibition of human oral cancer xenografts growth in vivo by compound 1a.

<p>(<b>A</b>) OEC-M1 tumor-bearing mice were administered s.c. with vehicle control (◊), 15 mg/kg (△), or 30 mg/kg (×) compound <b>1a</b> on days 0–4 for 5 days. The figure showed the relative tumor volume of control and compound <b>1a</b>-treated groups. (<b>B</b>) Caspase 3 activity of tissues from OEC-M1 tumor-bearing mice (on day 28 after inoculation). (<b>C</b>) The changes of body weight of the tumor-bearing mice. Body weight was measured for each animal every three days starting from the day of the initial compound <b>1a</b> treatment. All results are given as means ± SD; n = 6 for each group.*indicates a significant difference at the level of <i>p</i><0.05.