<p>(A) HepG2 cells were pretreated with GH or 30 min or 4 hours and harvested after insulin stimulation for 10 min. (B) Cells were transfected with wild type PTEN or PTEN mutant C124S, and harvested after insulin stimulation for 10 min. Densitometry absorbance values were averaged after they had been normalized to Akt for equal loading.</p
GH induces acute insulin resistance in skeletal muscle in vivo, which in rod...
<p>HG results in downregulation of the phosphorylation levels of Akt and Fox01,03a (A; Western blot ...
(A) Lysates from liver samples from WT and AnxA6-KO (AnxA6-/-) mice before (0 min; WT lane 1–4, AnxA...
<p>Cells were transfected with siRNA targeted for PTEN (A), PTEN mutant C124S (B) or wtPTEN (C), and...
<p>Mice were treated with daily hGH at 1 µg/g (controls received saline) for 3 weeks. (A) Fasting bo...
Chronic growth hormone (GH) therapy has been shown to cause insulin resistance, but the mechanism re...
<p>HepG2 cells were treated with 1, 4, 8 µg/ml of melittin and 0.5 µmol/ml TSA for 24 h. The p-Akt a...
<p>Mice were treated with bGH at 1 µg/g (controls received saline) daily for 3 weeks. (A) Fasting bo...
<p>(A) Immunoblotting analyses after incubation of HepG2 cells in the absence or presence of 5.5 mM ...
<p>(A). The effect of insulin alone on Akt phosphorylation after insulin treatment for 10, 20, 30, 6...
<p>A): Both wild-type HEK293 and HEK293/tau441 cells were treated with 1 µM dexamethasone (DEX) for ...
AbstractTo elucidate the effect of growth hormone (GH) on the insulin signal transduction pathway le...
Growth hormone (GH) is well known to induce in vivo insulin resistance. However, the molecular mecha...
<p>Transfection of HKC-8 cells with a double dominant negative Akt construct resulted in a decrease ...
<p>NG: normal glucose condition (5.5 mmol/L); HG: high glucose condition (28 mmol/L); A: ALA; LY: LY...
GH induces acute insulin resistance in skeletal muscle in vivo, which in rod...
<p>HG results in downregulation of the phosphorylation levels of Akt and Fox01,03a (A; Western blot ...
(A) Lysates from liver samples from WT and AnxA6-KO (AnxA6-/-) mice before (0 min; WT lane 1–4, AnxA...
<p>Cells were transfected with siRNA targeted for PTEN (A), PTEN mutant C124S (B) or wtPTEN (C), and...
<p>Mice were treated with daily hGH at 1 µg/g (controls received saline) for 3 weeks. (A) Fasting bo...
Chronic growth hormone (GH) therapy has been shown to cause insulin resistance, but the mechanism re...
<p>HepG2 cells were treated with 1, 4, 8 µg/ml of melittin and 0.5 µmol/ml TSA for 24 h. The p-Akt a...
<p>Mice were treated with bGH at 1 µg/g (controls received saline) daily for 3 weeks. (A) Fasting bo...
<p>(A) Immunoblotting analyses after incubation of HepG2 cells in the absence or presence of 5.5 mM ...
<p>(A). The effect of insulin alone on Akt phosphorylation after insulin treatment for 10, 20, 30, 6...
<p>A): Both wild-type HEK293 and HEK293/tau441 cells were treated with 1 µM dexamethasone (DEX) for ...
AbstractTo elucidate the effect of growth hormone (GH) on the insulin signal transduction pathway le...
Growth hormone (GH) is well known to induce in vivo insulin resistance. However, the molecular mecha...
<p>Transfection of HKC-8 cells with a double dominant negative Akt construct resulted in a decrease ...
<p>NG: normal glucose condition (5.5 mmol/L); HG: high glucose condition (28 mmol/L); A: ALA; LY: LY...
GH induces acute insulin resistance in skeletal muscle in vivo, which in rod...
<p>HG results in downregulation of the phosphorylation levels of Akt and Fox01,03a (A; Western blot ...
(A) Lysates from liver samples from WT and AnxA6-KO (AnxA6-/-) mice before (0 min; WT lane 1–4, AnxA...