Downregulation of NO/cGMP/PKG pathway in the penis of Sickle mice.

<p>Baseline calcium-dependent (constitutive) NOS activity (a), cGMP production (b), PDE5 activity (c), and PKG activity (d) are reduced in the penis of Sickle compared to WT and Hemi mice. Each bar represents the mean ± SEM of 5 mice using ANOVA post-hoc Tukey test. *<i>P</i><0.05 vs. WT and Hemi.