The ICAM-5 ectodomain affects an increase in mini excitatory post synaptic current (mEPSC) frequency.

<p>Stimulation of rat hippocampal neurons with 1 µg/ml ICAM-5 ectodomain (60 min. pretreatment) is associated with an increase in mEPSC frequency. In these experiments, 1,468 events from 11 control cells and 2353 events from 16 ICAM-5 stimulated cells were evaluated using standard techniques [74]. Representative tracings are shown in (A) while the average mEPSC frequency is shown in (B) and amplitude in (C). The difference between mEPSC frequency in control and ICAM treated neurons was significant (*<i>p</i> < 0.05, Student’s <i>t</i> test).