Changes in cytokines mRNA expression levels in the ears of AD mice by vaccination of rhPIV2/Ag85B.
- Hiroshi Kitagawa (190936)
- Mitsuo Kawano (429938)
- Keiichi Yamanaka (110955)
- Masato Kakeda (190941)
- Kenshiro Tsuda (110951)
- Hiroyasu Inada (429939)
- Misao Yoneda (429940)
- Tadashi Sakaguchi (429941)
- Akina Nigi (429942)
- Koumei Nishimura (429943)
- Hiroshi Komada (429944)
- Masato Tsurudome (429945)
- Yasuhiro Yasutomi (209251)
- Tetsuya Nosaka (429946)
- Hitoshi Mizutani (110972)
Publication date
July 2013
DOIAbstract
<p>Cytokines: IL-4 (panel A), IFN-γ (panel B), IL-10 (panel C), TGF-β (panel D), TNF-α (panel E), MIP2-α (panel F), IL-2 (panel G), IL-17 (panel H), mRNA expression in the ear lesions measured with Quantitative RT-PCR. Expressions of IL-4, TNF-α and MIP2-α mRNA were significantly decreased in the ear skin treated with intra-nasally rhPIV2/Ag85B treated group compared to those of control groups. Meanwhile, the expression levels of mRNA of IFN-γ, IL-10, TGF-β and IL-2 were significantly elevated in rhPIV2/Ag85B intra-nasally treated group compared to those of control groups. *P<0.05, **P<0.01, ***P<0.001.</p
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