<i>Bdnf</i> gene deficiency does not alter amyloid pathology in <i>APdE9</i> mice.

<p><b>A)</b> Example of an amyloid plaque (green) in the hippocampus surrounded by phosho-tau positive dystrophic neurites (red) in an <i>APdE9</i> mouse carrying both <i>Bdnf</i> alleles (A+Bw). Scale bar = 20 µm. <b>B)</b> Same in a mouse with only one <i>Bdnf</i> allele (A+B−). <b>C)</b> Amyloid load in the hippocampus expressed as % of examined surface area in <i>APdE9</i> mice carrying two <i>Bdnf</i> alleles (A+Bw) or only one (A+B−) allele. <b>D)</b> Phospho-Tau positive surface area around amyloid plaques in the anterior cingulate cortex (expresses as % of the combined plaque surface area) of <i>APdE9</i> mice carrying two (A+Bw) or one (A+B−) <i>Bdnf</i> alleles.