Effects of IL-21 on blood and intestinal T cell levels in SIV-infected RMs.

<p>Longitudinal assessment of the percentages (<b>A, C</b>) and absolute numbers expressed as cells per µl (<b>B, D</b>) of circulating CD4⁺ (<b>A, B</b>) and CD8⁺ (<b>B, D</b>) T cells in IL-21-treated and controls RMs. (<b>E–F</b>) Longitudinal assessment of intestinal CD4⁺ T cells expressed both as fraction of total CD3⁺ T cells (<b>E</b>) and as fold change relative to the percentages of CD4⁺ T cells at wk2 (<b>F</b>). IL-21-treated animals are depicted in orange, controls in black. Shaded area represents time of IL-21 treatment. Averaged data are presented as mean ± SEM.