Transcriptional activity of PPARα, SREBP-1c, and ChREBP in hepatocytes.

<p>Hepatocytes were treated with acetate and BML-275 and divided into a control group (0 mM acetate), a low-dose acetate treatment group (1.8 mM acetate), a medium-dose acetate treatment group (3.6 mM acetate), a high-dose acetate treatment group (7.2 mM acetate), a BML-275 group (10 μM BML-275), and a BML-275+acetate group (10 μM BML-275+3.6 mM acetate). Acetate (sodium acetate) was used in the form of neutralized acetic acid to avoid changing the pH of the medium. A and B: EMSA results for PPARα. C and D: EMSA results for SREBP-1c. E and F: EMSA results for ChREBP. * <i>p</i><0.05, ** <i>p</i><0.01 versus the control group.