The effect of STAT3α M206K mutation on the sensitivity of DLBCL cells to JAK2 inhibitor TG101348.

<p>(<b>A–B</b>) The effect of JAK2 inhibitor TG101348 on STAT3 dephosphorylation was assessed in WT STAT3α^WT and mutant STAT3α^M206K in stably transfected HEK-293T cells (<b>A</b>) and transiently transfected Ly3 cells (<b>B</b>). Data were repeated three times. (<b>C</b>) The effect of the overexpression of WT STAT3α^WT and mutant STAT3α^M206K on cell proliferation in the presence or absence of JAK2 inhibitor TG101348. Bars represent mean ± SD from 4 replicates. The experiment was repeated two times (**P = 0.0023). The data were analyzed by the two-tailed unpaired Student's t test.