Three-dimensional principal component analysis plots depicting the correlation network of analytes significantly different between fast and slow culture converters of African and Eurasian ancestry during intensive phase anti-TB treatment.

<p>Plots for patients of African and Eurasian ancestry are shown in panels A and B, respectively. Individual points represent a single analyte. The distance between analytes is a measure of their Pearson correlation coefficients. Lines link analytes to their nearest neighbour, the analyte with the most similar pattern of change during the course of treatment. Each analyte is coloured according to its R-statistic value, calculated by rank regression interaction analysis. The concentration of analytes coloured blue is lower in patients with slow vs. fast sputum culture conversion, while the concentration of those coloured yellow is higher in patients with slow vs. fast sputum culture conversion. Component vectors are displayed, along with a % figure signifying the proportion of the variability in the data that each component accounts for.