Activity of Maraviroc in MDM.

<p><i>In vitro</i> efficacy of Maraviroc in MDM cultures. The bars represents the percentage of viral inhibition (p24 production pg/ml) in presence of Maraviroc, AMD3100 and AZT at different concentrations, considering the untreated as 100. Mean values of at least 3 experiments for each isolate are shown. Error bars indicating inter-experimental standard deviations are shown. Maraviroc median IC₅₀ and IC₉₀ values of 3 different experiments are also shown. The False Positive Rate (FPR) values are based on the V3 sequences and calculated with Geno2Pheno algorithm. The phenotypic tropism was evaluated on astroglioma U87MG-CD4⁺-CCR5⁺−/CXCR4⁺-expressing cells (DR: R5⁺X4; D: R5/X4; DX: R5/X4⁺).*Antiviral activity against X4-tropic viruses (#16 and HIV_IIIB) was not evaluated because due to their low replication.