Effects of extended prophylaxis with different doses of mDEF201 on tissue parameters during a vaccinia virus lower respiratory infection (initiated by a 50-µl i.n. virus inoculation) in mice.

<p>Single 50-µl i.n. treatments (PFU/mouse) were given on the day indicated prior to virus challenge. Determinations were made five days after infection. A = lung weight, B = lung hemorrhage score, C = liver virus titer, D = lung virus titer, E = snout virus titer, F = spleen virus titer. Virus titers are expressed as log₁₀ PFU/g of tissue. The limits of detection for the assays approached 10² PFU/g (most liver and spleen samples from mDEF201-treated mice did not have detectable virus present). The horizontal bars on the figures represent means values (N = 5 per group). *P<0.05, **P<0.01, ***P<0.001, compared to placebo.