Ingenuity network analysis constructed using significant down-regulated genes (BH<0.05) founded during hASC culture evolution.

<p>The top network functions were Hematopoietic cell lineage, Cell adhesion molecules, Leucocyte transendothelial migration and Complement and coagulation cascades. B2M = beta-2-microglobulin; BCR = breakpoint cluster region; CD14 = monocyte differentiation antigen CD14; CD3 = T-cell surface glycoprotein CD3 epsilon chain; EPOR = erythropoietin receptor; ERK1/2 = mitogen activated protein kinase; EZR = ezrin; F13A1 = coagulation factor XIII, A1 polypeptide; FCRLA = Fc receptor-like A; FXN = frataxin, nuclear gene encoding mitochondrial protein; FYN = tyrosine-protein kinase Fyn; GRM1 = glutamate receptor, metabotropic 1; GZMB = granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); HBEGF = heparin-binding EGF-like growth factor; HLA-DRB1 = MHC class II antigen HLA-DRB1 beta 1; HLA-F = HLA class I histocompatibility antigen, alpha chain F; IFNGR1 = Interferon gamma receptor 1; IGF1 = insulin-like growth factor 1 (somatomedin C); IL10RA = interleukin 10 receptor, alpha; IL13 = interleukin 13; IL1R2 = interleukin 1 receptor, type I; Immunoglobulin = Immunoglobulin; Karyopherin beta = nucleo cytoplasmic transporter; lgG = inmunoglobulin G; lgm = immunoglobulin M; Mapk = Mitogen-activated protein kinase; NFKB = NF-kappa-beta; NFKB1 = nuclear factor NF-kappa-B p105 subunit; P38MAPK = map kinase p38; PI3K = phosphatidylinositol 4-phosphate 3-kinase; PIK3R3 = phosphatidylinositol 3-kinase regulatory subunit gamma; PLCG2 = 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; STAT5A = signal transducer and activator of transcription 5B; TCR = T cell antigen receptor; VEGF = vascular endothelial growth factor. The grey nodes are the genes classified as significant. The asterisk (*) indicates the degree of down-regulation.