Isoproterenol induced cardiac hypertrophy and dysfunction in mice.

<p>(A). Left ventricular posterior wall thickness in end-diastolic (LVPW;d) significantly increased from 3 days to 84 days after ISO treatment; (B). Fractional shortening% (FS%) significantly increased during earlier stages upon ISO treatment, but reduced at 84 days, as compared with sham; (C) Ratio of heart weight to body weight (HW/BW) and (D) Ratio of heart weight to tibia length (HW/TL) of ISO groups was markedly higher than that of sham groups. *P<0.05, **P<0.01, ***P<0.001, compared with sham at the same time points. ^#P<0.05, ^###P<0.001, compared with ISO group at 84 days. ISO, isoproterenol.