Summary of interactions of Hog1PP with cell cycle components.

<p>Hog1PP phosphorylates Sic1, which results in accumulation of Sic1 and an arrest in G1 phase. Also, Hog1PP prevents the formation of the Hsl1-Hsl7 complex by phosphorylating Hsl1. This leads to the accumulation of Swe1, due to the double negative link between Hog1PP and Swe1. As a consequence, the cell is arrested before the G2/M transition. Transcriptional downregulation of <i>CLN2</i> by Hog1PP influences the cell cycle progression in two different ways: first, it causes Sic1 to be less phosphorylated and more active. This inhibits the cell cycle transition to the S phase. Second, it influences indirectly the timing of the formation of the Hsl1-Hsl7 complex, which is important for the transition to the G2/M phase. Moreover, the downregulation of Cdc28-Clb2 by Hog1PP can cause SBF/MBF to be active for an extended duration, and therefore, cell cycle arrest before the G2/M transition.