Phenotype.

<p>Results are expressed as Mean ± SEM. (a) Body weight. There is no significant difference between TG and WT control rats. (b) Locomotor activity. Compared to WT, TG rats have a higher total activity at one month followed by a lower activity starting at 4 months of age. (c-d) Rotarod. Presented are the latency to fall off the rod during (c) constant speed (12 r.p.m) and (d) accelerating speed (4 - 40 r.p.m). A significant difference between groups was present already at 2 months of age [constant speed (2 months: t= 3.373, P< 0.001; 3 months: t= 3.53, P< 0.01; 4 months: t= 4.798; P< 0.001; 6 months: t=5.433; p< 0.001 and 9 months: t= 2.742, P< 0.05); accelerating speed (1 month: t= 1.066, P> 0. 1; 2 months: t= 4.172, P< 0.001; 3 months: t= 3.549, P< 0.01; 4 months: t= 6.493, p< 0.001; 6 months: t= 4.263, P< 0.001 and 9 months: t= 3.015, P< 0.01)]. Asterisks indicate significant differences between WT and TG rats (*p < 0.05; **p < 0.01 and ***p < 0.001).