Role of functional type I IFN response in the protection elicited by rMVA-Gn/Gc.

<p>(A) Detection of IFN-α in 129Sv/Ev mice vaccinated with a single dose of rMVA-Gn/Gc vaccine. Kinetics of ELISA IFN-α levels (A) and antiviral activity (B) in pooled sera from immunized mice. (B) Survival curves upon RVFV lethal challenge in vaccinated 129Sv/Ev wt (C) or IFNAR^−/− mice (D). The mice were vaccinated with a single dose administration and challenged as described. Statistical significance was considered when p<0.05 as determined by the log rank (Mantel-Cox) test.