<p>(a) Plots for a well oxygenated microenvironment (no hypoxia, OMF = 1 in the <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003120#pcbi.1003120.e064" target="_blank">equation (12)</a>) (cells killed = 621), (b) plot assuming no cell-cycle delay for repair after the radiation (cells killed = 516), (c) plots assuming there is no cell-cycle phase-specific sensitivity for repair after the radiation ( in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003120#pcbi.1003120.e064" target="_blank">equation (12)</a>) (cells killed = 1361) and (d)plots when there is no DNA repair after the radiation ( for all doses in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1...
A kinetic repair-misrepair-fixation (RMF) model is developed to link double-strand break (DSB) induc...
Ionising radiation can produce a number of effects in living cells and organisms. One way to investi...
Despite the intensive use of radiotherapy in clinical practice, its effectiveness depends on several...
<p>(<b>a</b>) Overview of the cell cycle regulation, cell responses to environmental factors and rad...
<p>(a) experimental results from Chaudhry <a href="http://www.ploscompbiol.org/article/info:doi/10.1...
<p>Each graph shows the mean % of cells showing γ-radiation-induced damage (▴). A cell was considere...
<p>(A) Survival curves in HeLa-Fucci cells treated with KPU-300 after irradiation. Cells were treate...
In this paper we use a hybrid multiscale mathematical model that incorporates both individual cell b...
<p>Black circles mark cell cycle checkpoints. Cells can enter and leave quiescence in response to th...
<p>Each graph shows the mean % of cells showing γ-radiation-induced damage (▴). A cell was considere...
<p>(A, B) U87R cells has more foci number than U87 cells. Indicated cells were exposed to several ra...
<div><p>In this paper we use a hybrid multiscale mathematical model that incorporates both individua...
<p>(A) Clonogenic assays of CL1-0 and CL1-5 cells treated with 0, 2, 5, and 10 Gy radiation. The sur...
We have investigated the dose rate effects on cell damage caused by photon-beam irradiation. During ...
Most studies that aim to understand the interactions between different types of photon radi-ation an...
A kinetic repair-misrepair-fixation (RMF) model is developed to link double-strand break (DSB) induc...
Ionising radiation can produce a number of effects in living cells and organisms. One way to investi...
Despite the intensive use of radiotherapy in clinical practice, its effectiveness depends on several...
<p>(<b>a</b>) Overview of the cell cycle regulation, cell responses to environmental factors and rad...
<p>(a) experimental results from Chaudhry <a href="http://www.ploscompbiol.org/article/info:doi/10.1...
<p>Each graph shows the mean % of cells showing γ-radiation-induced damage (▴). A cell was considere...
<p>(A) Survival curves in HeLa-Fucci cells treated with KPU-300 after irradiation. Cells were treate...
In this paper we use a hybrid multiscale mathematical model that incorporates both individual cell b...
<p>Black circles mark cell cycle checkpoints. Cells can enter and leave quiescence in response to th...
<p>Each graph shows the mean % of cells showing γ-radiation-induced damage (▴). A cell was considere...
<p>(A, B) U87R cells has more foci number than U87 cells. Indicated cells were exposed to several ra...
<div><p>In this paper we use a hybrid multiscale mathematical model that incorporates both individua...
<p>(A) Clonogenic assays of CL1-0 and CL1-5 cells treated with 0, 2, 5, and 10 Gy radiation. The sur...
We have investigated the dose rate effects on cell damage caused by photon-beam irradiation. During ...
Most studies that aim to understand the interactions between different types of photon radi-ation an...
A kinetic repair-misrepair-fixation (RMF) model is developed to link double-strand break (DSB) induc...
Ionising radiation can produce a number of effects in living cells and organisms. One way to investi...
Despite the intensive use of radiotherapy in clinical practice, its effectiveness depends on several...