Mutation of miR-133a predispose white preadipocytes to become adaptive beige adipocytes upon differentiation.

<p>qPCR analysis of relative gene expression in inguinal WAT tissue (n = 3 pairs) and cultured WAT adipocytes from SVF (n = 4 pairs) of wildtype (WT) and miR-133a knockdown (KO; <i>miR-133a1^−/−a2^+/−</i>) mice. (A) miR-133a in ingWAT, (B) BAT marker genes in ingWAT, (C) beige adipocyte marker genes, <i>CD137</i>, <i>Tmem26</i> and <i>Tbx1</i>, in ingWAT. (D) <i>Ucp1</i> and (E) other BAT marker gene expression in adipocytes differentiated from stromal vascular cells of ingWAT. *P<0.05, **P<0.01.