Anatomical regions exhibiting significant differences of cortical shape complexity between non-remitting depressed patients and healthy controls.

<p>The curvedness values significantly differed between non-remitting patients and healthy controls in the the right middle frontal gyrus (Frontal_Mid_R), the orbital part of right inferior frontal gyrus (Frontal_Inf_Orb_R), the left gyrus rectus (Rectus_L), and the right calcarine fissure and surrounding cortex (Calcarine_R) in the sucal pits. Significant differences also existed in the gyral saddle parts of the right thalamus (Thalamus_R) and the left Heschl gyrus (Heschl_L) and the gyral nodes of the right anterior cingulate and paracingulate gyri (Cingulum_Ant_R). In the triangular part of left inferior frontal gyrus (Frontal_Inf_Tri_L), we also discovered significant differences in the gyral saddle and sulcal saddle areas, respectively. All areas exhibiting significant differences were shown in (A) posterior, (B) anterior, (C) superior, (D) inferior (E) right-lateral, (F) left-lateral, (G) left-medial, and (H) right-medial views.