Tumor vascular permeability is reduced in anti-VEGF-A but not anti-VEGF-C treated animals.

<p>(A) Representative near-infrared fluorescence images of C6 tail xenograft tumors from indicated groups imaged 24 hours post 100 µL I.V. injection of AngioSense680. Animals were dosed weekly with indicated antibody starting two days post xenograft implantation, then imaged three weeks post implantation. Scale bar equals 5 mm. (B) Average fluorescence intensities within xenograft tumors across treatment conditions: control IgG, 4,746.75±388.66; anti-VEGF-C (VC4.5), 4,888.58±282.69; Anti-VEGF-A, 3,005.78±193.09. Bar graphs represent mean ± SEM, n = 6 animals per group.