Expressions of total and phosphorylated p70S6K in clinical TKI-sensitive and -resistant lung adenocarcinoma tumor tissues.

<p>(A) Summary of the tumors in gefitinib and erlotinib-treated patients, including three drug-sensitive and -resistant cases, respectively. Case 3 was a paired sample before and after TKI treatment. ADC represents adenocarcinoma. (B) Expression of total and phosphorylated p70S6K in the EGFR TKI-sensitive cases. The upper panel represents total p70S6K, and the lower panel represents phosphorylated p70S6K. (C) Expression of total and phosphorylated p70S6K in the EGFR TKI-resistant cases. The upper panel represents total p70S6K, and the lower panel represents phosphorylated p70S6K. ADC represents adenocarcinoma; S and R represent sensitive case and resistant case respectively. Scale bars, 50 µm.