Oscillations persist under SK current blockade.

<p>(A) The blockade moderately increases the frequency of oscillations. (B) A very weak applied depolarization (320 pA) is enough to block the oscillations. (C) NMDA receptor activation elevates the frequency as effectively as in the presence of the SK current. (D) A moderate NMDAR activation rescues the neuron from the blockade of oscillations caused by applied depolarization. (E,F) The dependence of the frequency on the NMDAR conductance and the applied current. The plots are similar to Fig. 2D and Fig. 4C respectively, but both horizontal scales are expanded and depolarization block occurs at lower values than with the SK current.