Genetic deletion of <i>Egfr</i> suppressed cyclophosphamide-induced follicular apoptosis and p53 immunopositivity.

<p>Control (A top panels, C) or mutant (A bottom panels, D) skin, 2 (A left and middle panels,B-D) or 4d (A right panels) after vehicle or cyclophosphamide labeled for TUNEL in green with DAPI in gray (A) or p53 in green with DAPI in gray (C-D). TUNEL-positive cells 2 d after cyclophosphamide (arrowheads), were reduced at 4d (A). B) Quantification of TUNEL-positive bulb cells at 2d (N = 3 mice). *Significantly different using Student’s t-test, where P≤0.05. p53 localized to the bulb of controls (C right) and mutants (D right) 2d following cyclophosphamide (arrowheads). CYP indicates cyclophosphamide treatment. Scale bar indicates 50 µm.