Far-UV CD spectra of ataxin-3 variants in increasing concentrations of SDS.

<p>The far-UV CD spectra for (a) ataxin-3(Q64), (b) ataxin-3(Q15) and (c) Josephin were measured at 37°C with increasing concentrations of SDS; 0 mM SDS (<i>black solid line</i>), 1 mM SDS (<i>black dotted line</i>), 5 mM SDS (<i>grey solid line)</i> or 10 mM SDS (<i>grey dashed line</i>). The final protein concentration was 30 µM and the spectra measured with a path length of 0.1 mm.