Ryp proteins are required for expression of yeast-phase specific genes.

<p>(A) Transcriptional profile comparisons of wild-type cells grown at 37°C (WT-37), wild-type cells grown at room temperature (WT-RT), and <i>ryp1</i>, <i>ryp2</i>, and <i>ryp3</i> mutants grown at 37°C represented as a heatmap. For a complete list of YPS and FPS genes see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001614#pbio.1001614.s008" target="_blank">Table S1</a> (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001614#s4" target="_blank">Materials and Methods</a> for bioinformatics analysis). (B) Select set of YPS genes involved in virulence is shown as a heatmap. Log2-based color scale is shown. (C) Phase-specific genes listed in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001614#pbio.1001614.s008" target="_blank">Table S1</a> were subjected to analysis for GO term enrichment. Top five GO terms and enrichment <i>p</i> values are shown for both YPS and FPS genes. (D) Correlation between transcriptional profiles of YPS and FPS genes in <i>ryp</i> mutants grown at 37°C and wild-type cells grown at RT are presented as scatter plots with Pearson correlation coefficients (r).