Network analysis of drug-induced gene expression profiles.

<p>(<b>A</b>) Drug-induced gene expression profiles tested in MCF7 (breast cancer) cells (nodes) are linked by shared expression patterns to a cluster exemplar (line width proportional to Pearson correlation) representing their characteristic response. Clusters enriched for literature or experimentally annotated hERG inhibitors are outlined in red. (<b>B</b>) Drug induced gene expression profiles generated from MCF7, PC3 (prostate cancer), and HL60 (leukemia) cell lines are clustered as in (<b>A</b>), with cell of origin indicated by node shape.