Effect of receptor-associated protein (RAP) on the expression of E-cadherin and α-SMA in myeloma light chain exposed human renal proximal tubule epithelial cells.

<p>RAP, 1 µM, prevented LC induced decrease in the epithelial cell marker E-cadherin (<b>A</b>), and reduced the increased expression of myofibroblast marker α-SMA (<b>B</b>), demonstrating that RAP protected cells from LC-induced EMT (representative blot from 3 experiments). Quantitative densitometric measurement of the effect of RAP pre-treatment followed by κ-LC in HK2 cells on the production of E-cadherin (<b>C</b>) and α-SMA (<b>D</b>) proteins. **p<0.01 compared to κ-LC alone.