The importance of fibronectin matrix assembly in various cellular processes.

<p>Fibronectin matrix assembly regulates cell growth, cell matrix adhesion, cellular contraction, and matrix metalloproteases (MMP) expression. Decreased fibrillogenesis resulting in decreased MMP expression may itself also be responsible for inhibition of cellular contraction. The scFv Fn52RGDS acts in accordance with features suggestive of decreased fibrillogenesis.