Blockade of HIF-1α activity <i>in vivo</i> reduces lung eosinophilia induced by HDM exposure.

<p>Mice were treated with PBS or HDM intranasally for 5 weeks, and chetomin was administrated intraperitoneally 20 minutes prior to each challenge. IL-13 levels were measured by ELISA in lung tissue (panel A). Mean ± SEM number of eosinophils in the lung (panel B). IL-5 (panel C), eotaxin 2 (panel D) and eotaxin 2 (panel E) were measured in the lung tissue homogenates by ELISA. *represents <i>p</i><0.05. n = 4–8 mice per experimental group.