Functional inhibition of UNC5B reduces damage in myocardial IR.

<p><b>A</b>) Infarct size after IR in WT mice receiving antibody against UNC5B (2.5 µg/mouse) iv. 30 min before onset of surgery. Controls were treated with corresponding IgG antibody. Calculated is the percentage of necrotic tissue to AAR. <b>B)</b> and <b>C)</b> Correlating serum Troponin I and IL-6 levels of these mice. (n = 6 per group; *<i>P</i><0.05; ***<i>P</i><0.001 as indicated). <b>D)</b> Representative TTC stained heart slices of myocardial infarcts (blue/dark = retrograde Evans blue staining; red and white = AAR; white = infracted tissue) of the antibody treated mice.