Comparison between Normal, Cancer and Perturbed scenarios for Glioma.

<p>TS: Treated Scenario; NS: Normal Scenario; GS: Glioma Scenario. The green arrow heads are indicating the minimal combination of proteins which was inhibited in the drug treated perturbation analysis. (A) Represents number of Upstream activator proteins (Y-axis) activating the proteins (X-axis) representing significant variations. Compared to the normal scenario, proteins, SHH, SMO, GLI1, GLI2, and output proteins BMI, SNAI1, BCL2 and Cyclins, are activated by maximum number of upstream activator proteins. On drug treated perturbation of SMO, GLI1 and GLI2, the number of activators of the output proteins become zero. (B) Represents number of Upstream inhibitory proteins (Y-axis) inhibiting the proteins (X-axis) representing significant variations. The numbers of upstream inhibitor proteins in normal versus Glioma scenario remain same. Similar perturbation results are observed as in (A). (C) Represents number of Downstream proteins (Y-axis) activated by the proteins (X-axis) representing significant variations. The number of downstream proteins activated in normal versus Glioma remains same. On perturbation of SMO, GLI1 and GLI2, the number of downstream proteins activated by these proteins is reduced to zero. (D) Represents number of Downstream proteins (Y-axis) inhibited by the proteins (X-axis) representing significant variations. The number of downstream proteins inhibited in normal versus Glioma remains the same.