Genealogical tree and mutation analysis.

<p>Filled symbols represent patients with TRAPS; open squares and circles indicate healthy individuals. No clinical information was available for individuals from generations I and II. A sequencing chromatogram showing the mutation identified in family members III.2, III.3, III.4, III.6, III.7, III.8, III.9, III.11, IV.2, and IV.3 is presented below. The sequence in healthy relatives (III.1, III.5, III.10, IV.1) is shown as a control. The heterozygous transition generating the missense mutation is encircled.