Plasmatic levels of chemokines and cytokine ratios among HTLV-1-infected patients with skin lesions.

<p>Serum chemokines and cytokines quantitation were performed by CBA as described in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002328#s2" target="_blank">materials and methods</a>. The results are expressed as concentration in pg/mL (×10³) ± standard error of (A) CCL2, (B) CCL5, (C) CXCL8, (D) CXCL9, (E) CXCL10 in the serum of HTLV-infected patients and controls with infectious (L^(INF) = dark gray rectangles) and autoimmune (L^(AI) = black-gray rectangles) skin lesions as well as carriers and controls without skin lesions (L⁽⁻⁾ = light gray rectangles). Significant differences at <i>P</i><0.05 are highlighted by letters for difference of a group as compared to control L⁽⁻⁾ indicated by “a”, to control L^(INF) indicated by “b”, to control L^(AI) indicated by “c”, to HTLV-1+ L⁽⁻⁾ indicated by “d” and to HTLV-1+ L^(INF) indicated by “e”. The ratio between cytokines and IL-10 for all groups was calculated for (F) IL-1β, (G) IL-6, (H) IL-12, (I) TNF-α. Significant differences are highlighted by connecting lines.