<p>(<b>A</b>) OVX mice were sacrificed after 30 days of KMUP-1 treatment. Images of the longitudinal and transverse sections of the proximal tibia were obtained with a µCT. (<b>B</b>, <b>C</b>) Tibial trabecular bone mineral content (BMC) and bone volume/tissue volume (BV/TV, %) were quantified from data obtained by the µCT. All values are expressed as mean ± S.E.M. <sup>#</sup><i>P</i><0.05 compared with the Sham group;<sup> *</sup><i>P</i><0.05 compared with the OVX group.</p
<p>(A) μCT reconstruction of metaphyseal trabecular bone of tibia in wild type (WT) and PRBP mice. (...
<p>(<b>A</b>) The BMD of femoral metaphysis was measured by pDEXA and analyzed with Lunar Piximus. *...
<p>Eight-week-old mice were treated with either vehicle (veh), a single <i>Lactobacillus</i> (L) str...
<p>Histomorphometric data and serum biochemical markers were compared in sham-operated, OVX mice, an...
<p>(A) WT, MKK3−/− and MKK6−/− mice were subjected to ovariectomy and bone loss was calculated using...
<p>(A–D) MV or PTH (80 µg/kg) was administered to the Sham- or OVX-mice. The femurs were used for fu...
<p>(A) Tibial bone sections from sham and OVX-treated mice were stained and representative figures a...
<p>OVX mice were subcutaneously injected with vehicle, 15d-PGJ<sub>2</sub>, or E2 (10 μg/kg) for 10 ...
<p>(A–E) MV was orally administered to Sham- or OVX-mice for 4 weeks and femurs were used for furthe...
Oestrogen deficiency-related bone loss in the ovariectomized (OVX) mouse is a common model for osteo...
BACKGROUND: KMUP-1 is a xanthine derivative with inhibitory activities on the phosphodiesterase (PDE...
<div><p>Background</p><p>KMUP-1 is a xanthine derivative with inhibitory activities on the phosphodi...
KMUP-1 is a xanthine derivative with inhibitory activities on the phosphodiesterase (PDE) 3,4 and 5 ...
<p>Micro-computed tomography (μCT) analysis of the cortical bone at the midshaft of the intact femur...
<p>(<b>A</b>) Mature osteoclasts were treated with RANKL (10 ng/ml) and KMUP-1 <b>(</b>1–10<b> </b>µ...
<p>(A) μCT reconstruction of metaphyseal trabecular bone of tibia in wild type (WT) and PRBP mice. (...
<p>(<b>A</b>) The BMD of femoral metaphysis was measured by pDEXA and analyzed with Lunar Piximus. *...
<p>Eight-week-old mice were treated with either vehicle (veh), a single <i>Lactobacillus</i> (L) str...
<p>Histomorphometric data and serum biochemical markers were compared in sham-operated, OVX mice, an...
<p>(A) WT, MKK3−/− and MKK6−/− mice were subjected to ovariectomy and bone loss was calculated using...
<p>(A–D) MV or PTH (80 µg/kg) was administered to the Sham- or OVX-mice. The femurs were used for fu...
<p>(A) Tibial bone sections from sham and OVX-treated mice were stained and representative figures a...
<p>OVX mice were subcutaneously injected with vehicle, 15d-PGJ<sub>2</sub>, or E2 (10 μg/kg) for 10 ...
<p>(A–E) MV was orally administered to Sham- or OVX-mice for 4 weeks and femurs were used for furthe...
Oestrogen deficiency-related bone loss in the ovariectomized (OVX) mouse is a common model for osteo...
BACKGROUND: KMUP-1 is a xanthine derivative with inhibitory activities on the phosphodiesterase (PDE...
<div><p>Background</p><p>KMUP-1 is a xanthine derivative with inhibitory activities on the phosphodi...
KMUP-1 is a xanthine derivative with inhibitory activities on the phosphodiesterase (PDE) 3,4 and 5 ...
<p>Micro-computed tomography (μCT) analysis of the cortical bone at the midshaft of the intact femur...
<p>(<b>A</b>) Mature osteoclasts were treated with RANKL (10 ng/ml) and KMUP-1 <b>(</b>1–10<b> </b>µ...
<p>(A) μCT reconstruction of metaphyseal trabecular bone of tibia in wild type (WT) and PRBP mice. (...
<p>(<b>A</b>) The BMD of femoral metaphysis was measured by pDEXA and analyzed with Lunar Piximus. *...
<p>Eight-week-old mice were treated with either vehicle (veh), a single <i>Lactobacillus</i> (L) str...