Effect of JNJ7777120 on bone marrow repopulation 30 days after whole body irradiation.
- Diego J. Martinel Lamas (437886)
- Eliana Carabajal (437887)
- Juan P. Prestifilippo (437888)
- Luis Rossi (437889)
- Juan C. Elverdin (437890)
- Susana Merani (437891)
- Rosa M. Bergoc (437892)
- Elena S. Rivera (437893)
- Vanina A. Medina (437894)
Publication date
July 2013
DOIAbstract
<p>(A) Bone marrow histopathology. (a,e) Normal trophism of untreated, and (b,f) JNJ7777120-treated bone marrow. (c,g) Bone marrow of irradiated rats showing a reduced number of components and an important adipose replacement (red arrow head). (d,h) Bone marrow of treated and irradiated animals demonstrating significant preservation of bone marrow components and minor adipose replacement. (a–d) H&E staining. (e–h) PCNA immunoreactivity. Arrows indicate PCNA-positive cells. 630x-fold magnification. Scale bar= 20 µm. (B) Histopathological characteristics of rat bone marrow. Error bars represent the means ± SEM (*P<0.05, **P<0.001 vs. Untreated; <sup>#</sup> P<0.05 vs. Untreated-5Gy).</p
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