Effect of JAK3 inhibitor on plasma and gastro-intestinal tissue viral loads.

<p>Aliquots of the plasma samples obtained prior to and post administration of the JAK3 inhibitor from each of the 6 monkeys were assayed for levels of SIV (commercially performed). A) Reflects # of viral copies/ml of plasma obtained from each of the 6 monkeys at weekly intervals until week 6, bi-weekly until week 14 is illustrated using a log scale to highlight differences seen in monkeys with low viral loads B) Reflects # of viral copies/ml of plasma obtained from each of the 6 monkeys at weekly intervals until week 6, bi-weekly until week 14 is illustrated using an arithmetic scale to highlight differences seen in monkeys with high viral loads C) Reflects the viral copies/ng DNA isolated from a pool of colo-rectal biopsies from each of the 6 monkeys obtained prior to (baseline) and at weeks 1, 3, 6 and 12 post JAK3 inhibitor administration.