A subset of TRβ1 target genes that are inhibited by SIRT1 knockdown.

<p>Heat map representing results of array analysis performed on HepG2-TRβ1 cells treated +/− T₃ and SIRT1 siRNA and displaying probe sets in which T₃ response is inhibited by SIRT1 siRNA. Scale is shown at top. The first lane (1) represents T₃ responses obtained in the presence of control siRNA, second lane (2) represents T₃ responses obtained in the presence of SIRT1 siRNA. The third lane (3) represents comparison of mRNA expression levels in the presence of control siRNA or SIRT1 siRNA. Note that, in most instances in which SIRT1 inhibits these T₃ responses, this effect is not accompanied by SIRT1-dependent changes in basal gene expression.