A Small Molecule SIRT1 activator and inhibitor regulate expression of TRβ1 target genes.

<p><b>(A∼C)</b> qPCR analysis performed upon HepG2-TRβ cells treated with 100 µM resveratrol +/−T₃. Genes are indicated at top. <b>(D∼F)</b> As for 10A–C, except that cells were treated with 10 mM nicotimamide instead of resveratrol. Data are representative of at least two independent experiments. All values represent the mean ± SD of duplicate samples. *, <i>P</i> < 0.05; **, <i>P</i> < 0.01.