Differential effects of normal and cancer-associated endometrial fibroblast on EC cell proliferation.

<p>ECC-1 (<b>A</b>) and HEC-1A (<b>B</b>) cell lines and EC6-Ep (<b>C</b>) and EC14-Ep (<b>D</b>) primary endometrial cancer cells were tested with conditioned media prepared from cancer-associated fibroblasts (EC6-Fib, EC7-Fib, EC11-Fib and EC14-Fib) and normal endometrial fibroblast cell line (T-HESC) for 72 hours. Cell viability was examined using MTT assay and were normalized with control (media containing 2% FBS). CAFs shown are the average of all the four cancer-associated fibroblasts tested. Data, average; error bars, S.E.M. *, <i>P</i><0.005;. **, <i>P</i><0.0001. Data shown are representative of three independent experiments.