Imatinib co-treatment with cisplatin, but not doxorubicin, rescues follicle health.

<p>Control, cisplatin-treated (0.5 µg ml⁻¹) and doxorubicin-treated (0.05 µg ml⁻¹) cultured ovaries were cultured in the presence or absence of imatinib. (<b>A</b>)<b>:</b> Percentage of unhealthy follicles (clear); (<b>B</b>)<b>:</b> Total number of follicles (shaded). Bars denote mean+sem; n = 7 for all groups, stars denote significant differences relative to control (**p<0.01). (<b>C</b>)<b>:</b> Pathway by which imatinib could protect the ovary against the damaging effect of cisplatin more effectively than it could against the damaging effect of doxorubicin.