CYP-induced bladder overactivity is decreased in Trpc1/c4^−/− mice.

<p><b>A,</b> Typical urodynamic traces of WT and Trpc1/c4^−/− mice in vehicle or following CYP treatment. <b>B,C,</b> Analysis of intercontractile interval in vehicle (<b>B</b>) and CYP-treatment mice (<b>C</b>) in WT and Trpc1/c4^−/− mice shows that double knock-out mice are functionally less affected by CYP treatment. <b>D,</b> Typical muscle strip contractility traces of WT mice in control and in CYP_c rats activated by 10 nM of carbachol. The statistical analysis of carbachol-induced contraction of muscle strips did not show difference between the two genotypes in CYP_c mice. <b>E,</b> Typical traces of muscle strip contractility of WT mice stimulated with high KCl concentration (122 mM). There is no difference between WT and Trpc1/c4^−/− in control and CYP_c conditions.