Proteins encoded by the PRV genome and functional properties as predicted from comparative studies with selected reovirus prototype strains.

a<p>L1-M3 PRV gene segments are annotated according to mammalian reoviruses (MRV). PRV L1 has been changed to L3, and vice versa, compared to that suggested by <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0070075#pone.0070075-Palacios1" target="_blank">[1]</a>. PRV S-class gene segments are annotated according to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0070075#pone.0070075-Palacios1" target="_blank">[1]</a>. For mammalian reovirus (MRV), avian orthoreovirus (ARV) and grass carp reovirus (GCRV) several proteins are produced from alternative reading frames or by post-translational proteolytic cleavage. In the latter case, if the exact cleavage site is known, the lengths of both proteolytic fragments are included in the table.</p>b<p>T3D = Type 3 Dearing strain.</p>c<p>GCRV contains an eleventh genomic segment which encodes a non-structural protein, NS26. VP7 is homologues to σ3/σB.</p>d<p>Cytotoxic, nonfusogenic integral membrane protein <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0070075#pone.0070075-Key1" target="_blank">[96]</a>.