CTHRC1 activates RhoA activity.
- Yu-Ling Chen (399126)
- Ting-Huang Wang (439324)
- Hey-Chi Hsu (52813)
- Ray-Hwang Yuan (399127)
- Yung-Ming Jeng (197758)
Publication date
July 2013
DOIAbstract
<p>(A) Pull-down assay of Rho family proteins showed that knockdown of CTHRC1 inhibited the activation of RhoA, but not Rac1 or Cdc42. (B) Treating Huh7 cells with recombinant CTHRC1 (100 ng/ml) activated the RhoA pathway. (C) CTHRC1 enhanced phosphorylation of MLC2, a target of ROCK. (D) Pretreatment with a ROCK inhibitor Y2732 (5 µmol/L) abolished the invasion-promoting activity of CTHRC1.</p
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