Motor ability of Q175 mutants declines with age.

<p>A. The accelerating rotarod test revealed that the age-related motor deficits in the Q175 model take up to 12 months to appear. B. 9 month old Q175 Hom mutants take longer to traverse the challenging beam test than age-matched WT and Q175 Het mice. C. The number of errors made while crossing each segment of the beam are shown, with the widest part of the beam on the left (33 mm) and narrowing towards the right (6 mm). The beam lengths are not to scale. The number of errors made while crossing the challenging beam are higher in Q175 Hom mutants. * indicates <i>P</i><0.05 in <i>post hoc</i> pairwise comparisons with WT after an effect of genotype was detected by one way ANOVA, and ^∧ indicates differences (<i>P</i><0.05) between Q175 Het and Hom mice.