Representative waveforms of wheel running activity from 3 to 12 months of age.

<p>Average waveforms from 10 days of wheel running activity in LD are shown and standard errors across animals are indicated. The white/black bar on the top indicates the 12∶12 hr light:dark (LD) cycle, and gray shading in the waveforms indicates lights off. Sample sizes are the same as reported in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0069993#pone-0069993-t001" target="_blank"><b>Table 1</b></a>. From left to right: WT, Q175 Het and Hom. From top to bottom: 3, 6, 9 and 12 months of age.