MED1 Knockdown promotes fulvestrant-induced cell cycle arrest.

<p>(<b>A</b>) BT474-tet-shMED1 and ZR75-1-tet-shMED1 cells were treated with vehicle (Veh) or doxycycline or/and fulvestrant (+Ful, 5µM) and harvested for flow cytometry analysis. The representative histograms of cell cycle distribution were shown with the percentages of S-phase cells presented. (<b>B</b>) The bar graph of the percentages of S-phase cells in above treatment groups after normalizing to that of the vehicle control treatment. (n=3. *: P< 0.05; **: P< 0.01).