Dexamethasone increases mIPSC frequency in DMV neurons.

<p><b>A</b>. Continuous recording of mIPSCs observed at holding potential of -10 mV in the presence of tetrodotoxin (TTX; 1 µM). <b>B</b>. Recording of mIPSCs in the same cell after application of DEX (10 µM). <b>A₁</b> and <b>B₁</b> are temporally-expanded, 2 s sections from boxed areas of traces A and B, respectively. Recording pipette contained 140 mM Cs⁺. <b>C</b>. Cumulative frequency plots of the inter-event interval distribution for mIPSCs before and after application of DEX for the recording in A and B. A significant effect of DEX was detected in this cell using the Kolmogorov-Smirnov (K–S) test (<i>P</i><0.05). <b>D</b>. Change in mIPSC frequency observed 3 min after DEX application in DMV neurons that were determined to have responded to DEX by K–S test (n=8; p<0.05). <b>E</b>. The effect of DEX in responding cells as a function of concentration. The effect of the highest DEX concentration (10 µM) in the presence of kynurenic acid (KYN; 1 mM) is also shown. Numbers in parentheses above the bars indicate number of replicates; error bars indicate SE.