Exposure of prostate cancer cell lines to hypoxia induces production and release of miR-210 into the extracellular environment.
- Heather H. Cheng (419445)
- Patrick S. Mitchell (264819)
- Evan M. Kroh (419448)
- Alexander E. Dowell (439719)
- Lisly Chéry (439720)
- Javed Siddiqui (439721)
- Peter S. Nelson (167711)
- Robert L. Vessella (200698)
- Beatrice S. Knudsen (57643)
- Arul M. Chinnaiyan (59535)
- Kenneth J. Pienta (192948)
- Colm Morrissey (35516)
- Muneesh Tewari (16884)
Publication date
July 2013
DOIAbstract
<p><i>Left column,</i> miR-210 copies/ng RNA in LNCaP and VCaP human prostate cancer cell lines cultured in normoxic (20% O<sub>2</sub>) (white bars) or hypoxic (1% O<sub>2</sub>) (blue bars) conditions for 24, 48 or 72 hours. <i>Right column,</i> miR-210 copies/µl in filtered conditioned media corresponding to cellular samples. *, <i>P</i> value <0.05; **, <i>P</i> value <0.01; ***, <i>P</i> value <0.001 (Student’s t-test).</p
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